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Inhibition of aflatoxin biosynthesis by phenolic compounds
Author(s) -
Hua S. S. T.,
Grosjean O. K.,
Baker J. L.
Publication year - 1999
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.1999.00635.x
Subject(s) - syringaldehyde , aflatoxin , acetosyringone , biosynthesis , chemistry , mycotoxin , biochemistry , enzyme , food science , transformation (genetics) , gene , vanillin , agrobacterium
The phenolic compounds acetosyringone, syringaldehyde and sinapinic acid inhibited the biosynthesis of aflatoxin B 1 (AFB 1 ) by A. flavus . Acetosyringone was the most active among the three compounds, inhibiting aflatoxin level by 82% at 2 m mol l −1. The synthesis and accumulation of norsolorinic acid, an aflatoxin biosynthetic intermediate, was also inhibited. These results suggest that at least one step early in the AFB 1 biosynthetic pathway is inhibited by the phenolics.