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Use of the Malthus‐AT system to assess the efficacy of permeabilizing agents on the activity of antibacterial agents against Pseudomonas aeruginosa
Author(s) -
Ayres,
Sheila Payne,
Furr,
; Russell
Publication year - 1998
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.1998.00364.x
Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antibacterial activity , bacteria , antibacterial agent , pseudomonadales , biology , chemistry , antibiotics , genetics
The Malthus‐AT system provided a satisfactory method for examining the effects of permeabilizing agents on the activity of sub‐inhibitory concentrations of antibacterial agents against Pseudomonas aeruginosa G48. Under this system, disodium edetate potentiated the activity of chlorhexidine diacetate (CHA), cetylpyridinium chloride, para‐ chloro meta xylenol and triclosan. Nitrilotriacetic acid enhanced the activity of some of the antibacterials tested, whereas sodium polyphosphate markedly reduced the efficacy of CHA.