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Campylobacter jejuni 72Dz/92 cjaC gene coding 28 kDa immunopositive protein, a homologue of the solute‐binding components of the ABC transport system
Author(s) -
Pawelec,
JakubowskaMróz,
JagusztynKrynicka
Publication year - 1998
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.1998.00276.x
Subject(s) - campylobacter jejuni , biology , gene , cosmid , atp binding cassette transporter , campylobacter , akt1s1 , homology (biology) , periplasmic space , peptide sequence , gene product , coding region , syt1 , microbiology and biotechnology , genetics , hspa2 , escherichia coli , gene expression , bacteria , transporter
Screening of the Campylobacter jejuni 72Dz/92 cosmid gene bank enabled identification of the cjaC ( Camp. jejuni antigen C) gene encoding a highly immunogenic protein of apparent molecular mass 28 kDa. Gene bank searches indicated significant overall homology of the cjaC gene product, mainly to the Gram‐negative periplasmic solute‐binding proteins of the ABC transport system which recognize polar amino acids and opines. CjaC protein contains the motif LVAC at the end of the putative 19 amino acid signal sequence, which suggests that it might be a lipoprotein. In the 5′ flanking region of the cjaC gene, two potential promoter regions were observed. The cjaC gene is conserved among some isolates of three serotypes commonly isolated from humans (HL serotypes 1,4,71).