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Growth inhibition of Helicobacter pylori by apolyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)
Author(s) -
Takaji S.,
Hibasami H.,
Imoto I.,
Hashimoto Y.,
Nakao K.,
Ikemura N.,
Taguchi Y.,
Nakashima K.
Publication year - 1997
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.1997.00198.x
Subject(s) - library science , medicine , traditional medicine , computer science
The anti‐proliferative effect of methylglyoxal bis(cyclopentyl‐amidino‐hydrazone) (MGBCP), a multi‐enzyme inhibitor of polyamine biosynthesis, on the growth of Helicobacter pylori was investigated. MGBCP inhibited the cell growth of H. pylori in a dose‐dependent manner. The inhibition was partially reversed by the addition of spermidine. Synthesis of macromolecules, DNA, RNA and protein, was inhibited in the spermidine‐depleted H. pylori cells. These findings suggest that MGBCP exhibits an anti‐proliferative effect on H. pylori by suppression of macromolecule synthesis.