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TRV1 involvement in inflammatory pain: mechanisms and pharmacological modulation
Author(s) -
MorenillaPalao C.,
PlanellsCases R.,
GarcíaMartínez C.,
GarciaSanz N.,
FerrerMontiel A.
Publication year - 2003
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.85.s2.4_2.x
Subject(s) - trpv1 , ion channel , nociception , neuroscience , transient receptor potential channel , signal transduction , transduction (biophysics) , analgesic , receptor , medicine , microbiology and biotechnology , pharmacology , biology , biophysics
Vanilloid receptor I (TRPV1) is an integral membrane protein that integrates thermal and chemical stimuli. This molecular device is at the essence of cellular signalling at peripheral nerve terminals where it plays a central role in nociception. As expected, channel dysfunction is critically involved in pain transduction, specially in inflammatory pain. This notion is supported by genetic and pharmacological knock out data. As other ion channels, TRPV1 is a component of supramolecular assemblies that configure intraneuronal protein networks essential for signal transduction. As a result, a tremendous effort is being invested to identify the molecular components of the ion channel complex, and to validate them as therapeutic targets for better analgesic drugs. Current advances and discoveries in this exciting field will be highlighted, along with their implications for efficient and selective pain management.