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Abstracts: 1
Author(s) -
Strużyńska L.,
DąbrowskaBouta B.,
Sulkowski G.,
Rafałowska U.
Publication year - 2003
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.85.s2.26.x
Subject(s) - glutamine , glutamate receptor , neurotoxicity , neurotransmitter , gabaergic , glutamine synthetase , neurotransmission , neuroscience , chemistry , pharmacology , biochemistry , biology , toxicity , central nervous system , amino acid , inhibitory postsynaptic potential , receptor , organic chemistry
Lead (Pb) is a known neurotoxic agent, however, mechanisms of its neurotoxicity are still an open question. The aim of the study was to assess the function of nerve endings and astroglia in regard to the relationships between GABA, glutamate and glutamine using the rodent model of Pb toxicity. Synaptosomal processes of radioactive neurotransmitter transport, both GABA and glutamate, were impaired. Moreover, the uptake of glutamine, involved in the neuronal recycling of the neurotransmitters GABA and glutamate, decreased. However, evidences of astroglial activation (enhanced uptake of glutamate and activation of glutamine synthetase) were observed, together with parallel existing weakness of glutamine transport. The results suggest that the disturbances in GABAergic and glutamateric neurotransmission may be partially the effect of impaired neuronal–astrocytic interaction, mainly in intercellular trafficking of glutamine.