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In vitro 1 H magnetic resonance spectroscopy differences between meningeoma and astrocytoma
Author(s) -
Likavčanová K.,
Dobrota D.,
Liptaj T.,
Prónayová N.,
Galanda M.,
Belan V.
Publication year - 2003
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.85.s2.17_3.x
Subject(s) - astrocytoma , taurine , glutamine , inositol , creatine , nuclear magnetic resonance , glycine , nuclear magnetic resonance spectroscopy , in vivo magnetic resonance spectroscopy , chemistry , glutamate receptor , biochemistry , biology , glioma , magnetic resonance imaging , medicine , amino acid , cancer research , physics , receptor , radiology
Tumor transformation of the human brain cells causes different biochemical changes. Here we employed 1 H magnetic resonance spectroscopy to compare the presence of low molecular weight metabolites in meningeoma and astrocytoma tumors by measuring perchloric acid extracts of the cells. In 1 H spectra of meningeoma we detected high signal from lactate but were unable to detect any signal of NAA and creatine. In contrast, astrocytoma samples revealed significantly higher level of inositol and glycine and significant decrease in glutamate and glutamine compared with meningeoma but no presence of taurine. Our results suggest that 1 H MRS can provide useful information about biochemical changes in different types of brain tumors. Acknowledgements: This work was supported by the Grant Category C and Comenius University Grant No. X/2003.