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Sodium thiosulfate as an effective antioxidant substance at experimental mycotoxin zearalenon poisoning
Author(s) -
Karagyozyan M. K.
Publication year - 2002
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.81.s1.40_5.x
Subject(s) - chemistry , phospholipid , biochemistry , dopamine , antioxidant , monoamine oxidase , membrane , phosphatidylserine , stimulation , microsome , endocrinology , enzyme , biology
Mycotoxin zearalenon (MZ) in concentration 2.5–15.0 μg/mL of alcohol solution activates the reactions of monoamines biosynthesis, while 20.0–25.0 μg/mL of MZ has a contrarary effect. The molecular mechanism of changes noticed is conditioned by action of MZ on numerous proteins functioning in chromaffin granules mainly in their membranes, such as the cytochrome B561, an acidic cooper‐containing protein and the membrane‐bound form of dopamine‐β‐monooxigenase, which catalyses the reaction of transformation of dopamine into noradrenaline. It has been established also that in the brain mitochondrial and microsomal membranes the MZ induces pronounced abnormalities in the ratio of phospholipid‐phospholipid interrelations. These changes are conditioned by significant intensification of the phospholipase A2 and phosphatidylserine (PS) decarboxylase activites, with formation of high concentrations of lysophosphatidylcholines, free polyenic fatty acids, lipid peroxides and by increasing of PS quantity in the systems studied. Using on this background single intramuscular administration of 1.0 mL of 10.0% aquaus solution of sodium thiosulfate (ST) normalizes and establishes the initial level of phospholipid (PL) metabolism intensity. The content of PL in the investigated membranes remains unchanged if ST was administrated before the MZ poisoning modulation. Antioxidant properties of ST are conditioned in particular by elevation of PS quantity, which are of great importance in stimulation of cell respiratory function, hence the cell activity in general.