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Role of mycotoxin zearalenon poisoning in abnormalities of thromboplastic activity in rats and ways of their correction
Author(s) -
Karageuzyan K. G.,
Karagyozyan M. K.
Publication year - 2002
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.81.s1.40_4.x
Subject(s) - chemistry , medicine , sodium , endocrinology , biochemistry , pharmacology , biology , organic chemistry
Intravenous administration of alcohol solution mycotoxin zearalenon (MZ) in quantity of 5.0–15.0 μg/body weight to 46 white mongrel male rats weighing 180–200 g, significantly shorten the blood coagulation time (BCT) and increase brain and erythrocyte thromboplastic activity (TA). Our previous investigations have shown that neutral phospholipids (NPL) particularly, phosphatidylcholines (PC) and phosphatidylethanolamines (PE) accelerate the blood clotting process (BCP), while acidic phospholipids (APL) mainly phosphatidyserines, play the role of inhibitors of BCP. Brain tissue thromboplastins are the membrane‐bound PL‐dependent enzymes catalysing the process of blood unactive prothrombin transformation into the active thrombin. It is necessary to draw attention to the relationship between the coefficient NPL/APL quota and TA both in normal and pathological conditions. It was demonstrated that modulation of MZ poisoning in rats accompanied by activation of PC biosynthesis. This fact leads us to the conclusion that elevation of PE quantity under the conditions of MZ poisoning is accompanied also with partial involving of them into methylation processes and provides high concentrations of PC. Intramuscular single administration to poisoned rats of 1 mL of 10% water solution of sodium thiosulfate separately and especially in combination with the Ca ions precipitate of dsRNA in concentration 5.0–25.0 mg/kg leads to normalization of all abnormalities mentioned during the period of 2–4 h MZ intoxication.