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Secretion of locally synthesized neurohormone from neurites of peptidergic neurons
Author(s) -
Lee Wenjau,
Wayne Nancy L.
Publication year - 2004
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2003.02194.x
Subject(s) - aplysia , neurite , soma , prohormone , neuroscience , secretion , biology , microbiology and biotechnology , hormone , nervous system , neuron , endocrinology , biochemistry , in vitro
Local protein synthesis in neuronal processes is a common phenomenon and may play an important role in synaptic plasticity and hormonal regulation. We have used neuroendocrine bag cells of Aplysia californica as a model system to study local protein synthesis. In our previous work we found that bag cell neurites are capable of synthesizing and processing the prohormone of egg‐laying hormone (pro‐ELH). In the present study, we found that bag cell neurites are also capable of releasing locally synthesized pro‐ELH and ELH‐related products via both constitutive and regulated pathways. However, an electrical afterdischarge did not enhance local pro‐ELH synthesis, as it does in the bag cell soma. This is the first evidence that isolated neurites are capable of secreting locally synthesized proteins.