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Oligodendrocyte‐myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth
Author(s) -
Kottis Vicky,
Thibault Pierre,
Mikol Daniel,
Xiao ZhiCheng,
Zhang Rulin,
Dergham Pauline,
Braun Peter E.
Publication year - 2002
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2002.01146.x
Subject(s) - neurite , myelin , dorsal root ganglion , myelin oligodendrocyte glycoprotein , biology , oligodendrocyte , glycoprotein , microbiology and biotechnology , neuroscience , central nervous system , biochemistry , in vitro , spinal cord
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte‐myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.