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Selective reduction by isolation rearing of 5‐HT 1A receptor‐mediated dopamine release in vivo in the frontal cortex of mice
Author(s) -
Ago Y.,
Sakaue M.,
Baba A.,
Matsuda T.
Publication year - 2002
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2002.01128.x
Subject(s) - agonist , dopaminergic , dopamine , medicine , endocrinology , serotonin , receptor , 5 ht receptor , serotonergic , in vivo , monoaminergic , amphetamine , chemistry , neurotransmitter , autoreceptor , biology , microbiology and biotechnology
Serotonin (5‐HT) 1A receptors modulate in vivo release of brain monoaminergic neurotransmitters which may be involved in isolation‐induced aggressive behavior. The present study examined the effect of isolation rearing on the 5‐HT 1A receptor‐mediated modulation of dopamine (DA), 5‐HT and noradrenaline (NA) release in the frontal cortex of mice. The selective 5‐HT 1A receptor agonist ( S )‐5‐{3‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy}‐1,3‐benzodioxole HCl (MKC‐242) increased the release of DA and NA and decreased the release of 5‐HT in the frontal cortex of mice. The effect of MKC‐242 on DA release was significantly less in isolation‐reared mice than in group‐reared mice, while effects of the drug on NA and 5‐HT release did not differ between both groups. The effect of the other 5‐HT 1A receptor agonist 8‐hydroxy‐2‐(di‐ n ‐propylamino)tetralin on cortical DA release was also less in isolation‐reared mice than in group‐reared mice, and that of the drug on cortical 5‐HT release did not differ between both groups. In contrast to MKC‐242‐induced DA release, amphetamine‐induced increase in cortical DA release in vivo was greater in isolation‐reared mice. The present findings suggest that isolation rearing enhances the activity of cortical dopaminergic neurons and reduces selectively the 5‐HT 1A receptor‐mediated release of DA in the cortex.