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Developmental alteration of nerve injury induced glial cell line‐derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate
Author(s) -
Honma Masaru,
Namikawa, Kazuhiko,
Mansur, Khalil,
Iwata, Tatsuya,
Mori, Nozomu,
Iizuka Hajime,
Kiyama Hiroshi
Publication year - 2002
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2002.01043.x
Subject(s) - axotomy , glial cell line derived neurotrophic factor , neurotrophic factors , gdnf family of ligands , neuroscience , biology , nerve growth factor , neurotrophin , microbiology and biotechnology , receptor , central nervous system , biochemistry
Axotomy‐induced neuronal death occurs in neonatal motoneurons, but not in adult rat. Here we demonstrated that during the course of postnatal development, nerve injury induced down‐regulation of the glial cell line‐derived neurotrophic factor (GDNF) receptor GFRα1 in axotomized hypoglossal motoneurons of rat are gradually converted to the adult up‐regulation pattern of response. The compensatory expression of GFRα1 specifically in the injured motoneurons of neonates by adenovirus succeeded in rescuing the injured neurons without an application of growth factors. To the contrary, the nuclear antisense RNA for GFRα1 expression accelerates the axotomy‐induced neuronal death in pups. These findings suggest that the receptor expression response after nerve injury is critical for the determination of injured motoneuron fate.