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Complete inhibition of in vivo glioma growth by oncostatin M
Author(s) -
Friedrich Matthias,
Höss Norbert,
Stögbauer Florian,
Senner Volker,
Paulus Werner,
Ringelstein E. bernd,
Halfter Hartmut
Publication year - 2001
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2001.00202.x
Subject(s) - oncostatin m , in vivo , glioma , transfection , cancer research , biology , in vitro , cell growth , cell culture , microbiology and biotechnology , immunology , interleukin 6 , cytokine , biochemistry , genetics
We describe here the oncostatin M (OSM)‐dependent inhibition of in vivo tumour formation after intracerebral inoculation of glioblastoma cells in mice. We generated human glioblastoma cells transfected with the OSM gene under the control of a tetracycline‐response promoter. Upon removal of tetracycline from the medium, cells exhibited a differentiated cell morphology, while proliferation was significantly inhibited. After implantation of these cells into nude mice brains, large tumours developed in animals lacking OSM expression, whereas no tumour formation was observed in mice with induced OSM expression. Our results suggest that OSM exerts pronounced antitumorigenic effects on glioblastoma cells in vivo and provide arguments for a therapeutic application of OSM in humans.