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Isolation and Characterization of Novel Presenilin Binding Protein
Author(s) -
Kashiwa Atsushi,
Yoshida Hirotaka,
Lee Soon,
Paladino Toni,
Liu Yuanbin,
Chen Qi,
Dargusch Richard,
Schubert David,
Kimura Hideo
Publication year - 2000
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.2000.0750109.x
Subject(s) - presenilin , cytoplasm , biology , cell fractionation , hippocampus , cerebral cortex , immunohistochemistry , alzheimer's disease , gene , microbiology and biotechnology , genetics , neuroscience , disease , pathology , medicine , membrane , immunology
Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin (PS) gene. This suggests that an altered function of mutated PSs accounts for a fundamental process leading to AD. Here we identify a new PS binding protein, PBP, which is highly expressed in cerebral cortex and hippocampus. immunohistochemical studies and cell fractionation analysis show that PBP redistributes from cytoplasm to membranes in the presence of PS. In addition, PBP is deficient in the soluble fraction of sporadic AD brains.