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Extensive Alternative Splicing in the 5′‐Untranslated Region of the Rat and Human Neuropeptide Y Y 5 Receptor Genes Regulates Receptor Expession
Author(s) -
Parker Eric M.,
Xia Ling
Publication year - 1999
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1999.0730913.x
Subject(s) - neuropeptide y receptor , alternative splicing , receptor , exon , biology , untranslated region , 5 ht5a receptor , gene , rna splicing , three prime untranslated region , microbiology and biotechnology , messenger rna , genetics , neuropeptide , rna
: Neuropeptide Y (NPY) elicits a plethora of physiological effects by interacting with several distinct G protein‐coupled receptors. Activation of one of these receptors, the NPY Y 5 receptor, is thought to result in increased food intake, anticonvulsant effects, attenuation of opiate withdrawal, inhibition of neuronal activity, and alteration of renal function. Several alternatively spliced human and rat NPY Y 5 receptor cDNAs have been isolated that use different combinations of exons in the 5′‐untranslated region. The various human NPY Y 5 receptor cDNAs appear to be differentially expressed in different brain regions. The level of human NPY Y 5 receptor expressed transiently in COS1 cells was significantly influenced by the sequence of the 5′‐untranslated region. These results indicate that alternative splicing in the 5′‐untranslated region of the human and rat NPY Y 5 receptor genes occurs in a tissue‐specific manner and is one mechanism by which cells control the level of NPY Y 5 receptor expression.