Premium
Evidence for Oxidative Stress in the Subthalamic Nucleus in Progressive Supranuclear Palsy
Author(s) -
Albers David S.,
Augood Sarah J.,
Martin Deborach M.,
Standaert David G.,
Vonsattel Jean Paul G.,
Beal M. Flint
Publication year - 1999
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1999.0730881.x
Subject(s) - progressive supranuclear palsy , oxidative stress , lipid peroxidation , malondialdehyde , cerebellum , pathogenesis , subthalamic nucleus , medicine , endocrinology , pathology , chemistry , neuroscience , biochemistry , biology , parkinson's disease , atrophy , disease , deep brain stimulation
: Increased free radical production and oxidative stress have been proposed as pathogenic mechanisms in several neurodegenerative disorders. Free radicals interact with biological macromolecules, such as lipids, which can lead to lipid peroxidation. A well‐established marker of oxidative damage to lipids is malondialdehyde (MDA). We measured tissue MDA levels in the subthalamic nucleus (STN) and cerebellum from 11 progressive supranuclear palsy (PSP) cases and 11 age‐matched control cases using sensitive HPLC techniques. In PSP, a significant increase in tissue MDA levels was observed in the STN when compared with the age‐matched control group. By contrast, no significant difference between tissue MDA content was observed in cerebellar tissue from the same PSP and age‐matched control cases. These results indicate that lipid peroxidation may play a role in the pathogenesis of PSP.