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Sepsis Increases Intracellular Free Calcium in Brain
Author(s) -
Anderson Stasia A.,
Song ShengKwei,
Ackerman Joseph J. H.,
Hotchkiss Richard S.
Publication year - 1999
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1999.0722617.x
Subject(s) - sepsis , intracellular , proinflammatory cytokine , calcium , tumor necrosis factor alpha , calcium in biology , in vivo , pathophysiology , cytokine , inflammation , pathology , medicine , biology , chemistry , endocrinology , microbiology and biotechnology
Using magnetic resonance methods and a clinically relevantrodent model of sepsis, we have made in vivo measurements of increasedintracellular calcium in a pathologic state in the CNS. The intracellularcalcium concentration was increased nearly twofold in septic rat braincompared with controls ( p < 0.0001). This result, in a fullyintact functioning mammalian system, ties together a previous spectrum ofindirect evidence from numerous laboratories suggesting an important role forelevated intracellular calcium in sepsis. In addition, levels of theproinflammatory cytokine tumor necrosis factor‐α were elevated threefoldin septic rat brain ( p < 0.02), and electron microscopic examination revealed scattered injury in ∼0.25% of glial cells. These findings are discussed in light of the current understanding of the pathophysiology of sepsis.