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Histamine H 1 Receptor Binding Capacities in the Amygdalas of the Amygdaloid Kindled Rat
Author(s) -
Toyota H.,
Ito C.,
Yanai K.,
Sato M.,
Watanabe T.
Publication year - 1999
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1999.0722177.x
Subject(s) - amygdala , kindling , histamine , medicine , endocrinology , receptor , chemistry , histamine h1 receptor , stimulation , antagonist
The histamine H 1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decreases in K D and B max values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, the decreased K D value was sustained in the kindled nonstimulated amygdala. This decreased B max value 1 week after the last kindled seizure in nonstimulated amygdala may partly and transiently contribute to kindled seizure susceptibility. The decreased K D value in nonstimulated amygdala observed until 1 month after the last kindled seizure indicates the long‐lasting increment of binding affinity of the pyrilamine binding site of the histamine H 1 receptor in the steady state of kindled seizure susceptibility.