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F 4 ‐ Isoprostanes as Specific Marker of Docosahexaenoic Acid Peroxidation in Alzheimer's Disease
Author(s) -
NouroozZadeh Jaffar,
Liu Edwin H. C.,
Yhlen B.,
Änggåard Erik E.,
Halliwell Barry
Publication year - 1999
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1999.0720734.x
Subject(s) - isoprostanes , lipid peroxidation , docosahexaenoic acid , arachidonic acid , eicosapentaenoic acid , chemistry , oxidative stress , biochemistry , medicine , endocrinology , polyunsaturated fatty acid , fatty acid , enzyme
: F 2 ‐isoprostanes are prostaglandin‐likecompounds derived from free radical‐catalysed peroxidation of arachidonicacid. Peroxidation of eicosapentaenoic acid producesF 3 ‐isoprostanes, whereas peroxidation of docosahexaenoic acid wouldgive F 4 ‐isoprostanes. This study demonstrates the presence ofesterified F 4 ‐isoprostanes in human brain and shows that levels areelevated in certain brain cortex regions in Alzheimer's disease. Our data withAlzheimer's disease suggest that analysis of F 4 ‐isoprostanes will provide new opportunities to study lipid peroxidation in the neurodegenerative diseases.