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Continuous Treatment with Morphine Increases Diazepam Binding Inhibitor mRNA in Mouse Brain
Author(s) -
Katsura Masashi,
Hara Atsuo,
Higo Atsuko,
Tarumi Chihaya,
Hibino Yasushi,
Ohkuma Seitaro
Publication year - 1998
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1998.71062638.x
Subject(s) - morphine , diazepam , (+) naloxone , pharmacology , messenger rna , opioid , receptor , endocrinology , medicine , chemistry , gene , biochemistry
Effects of acute and chronic morphine treatment on the expression of diazepam binding inhibitor (DBI) mRNA in the mouse brain were examined. Cerebral DBI mRNA expression significantly increased in morphine‐dependent mice, and this increase is more remarkable in morphine‐withdrawn mice, whereas a single administration of morphine (50 mg/kg) produced no changes in the expression. Simultaneous administration of naloxone (3 mg/kg) with morphine completely abolished the increase in cerebral DBI mRNA expression observed in morphine‐dependent and ‐withdrawn mice. These results indicate that a chronic functional interaction between morphine and opioid receptors has a critical role in increases in DBI mRNA expression.