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GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems
Author(s) -
Hadjiconstantinou Maria,
Neff Norton H.
Publication year - 1998
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1998.70041335.x
Subject(s) - neuroscience , neurotransmitter , neuroprotection , in vivo , ganglioside , neurotrophic factors , neurotransmitter systems , central nervous system , biology , dopamine , biochemistry , receptor , microbiology and biotechnology
There is now substantial evidence that GM1 ganglioside is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in vitro model systems. Although the molecular mechanism(s) and the substrates for the neurotrophic activity of the gangliosides are not fully understood, the published experimental work suggests that GM1 has antineurotoxic, neuroprotective, and neurorestorative effects on various central neurotransmitter systems. This review focuses attention on studies reporting that GM1 restores neuronal integrity and function in the brain of lesioned young as well as aged animals. Critical analysis of these studies can provide guidance for future ganglioside research and may point to novel approaches for treating neuroinjury and a variety of degenerative conditions, including aging.