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Neonatal Oligodendrocytes Contain and Secrete Neuregulins In Vitro
Author(s) -
Raabe Timothy D.,
Clive Diana R.,
Wen Duanzhi,
DeVries George H.
Publication year - 1997
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1997.69051859.x
Subject(s) - neuregulin , paracrine signalling , biology , oligodendrocyte , neuregulin 1 , autocrine signalling , microbiology and biotechnology , progenitor cell , neuroglia , gene isoform , growth factor , neuroscience , stem cell , myelin , signal transduction , receptor , central nervous system , genetics , gene
The factors that influence the development of oligodendrocyte (OLG) progenitors into mature OLGs remain elusive. Recent evidence has suggested that neu differentiation factor (NDF), which is a member of the neuregulin family of growth factors, influences the development of glial cells, including Schwann cells, astrocytes, and OLGs. Neurons are postulated to be the source of neuregulins, because neurons closely interact with these glial cells during development. In this report, we have identified the mRNA for both isoform families of NDF in cultured neonatal (immature) OLGs. We have also demonstrated that cultured neonatal OLGs contain and secrete NDF protein. These data raise the possibility that NDF could be used in an autocrine/paracrine loop by neonatal OLGs during development for survival, proliferation, and/or differentiation.