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Effect of Cocaine on the Histaminergic Neuron System in the Rat Brain
Author(s) -
Ito Chihiro,
Onodera Kenji,
Sakurai Eiko,
Sato Mitsumoto,
Watanabe Takehiko
Publication year - 1997
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1997.69020875.x
Subject(s) - histaminergic , histamine , nucleus accumbens , striatum , neuron , histamine h3 receptor , pharmacology , chemistry , histidine decarboxylase , histamine n methyltransferase , dopamine , neuroscience , endocrinology , medicine , histidine , psychology , histamine h2 receptor , biology , biochemistry , antagonist , receptor , amino acid
To examine the effect of cocaine on the brain histamine neuron system, histamine levels and histamine N ‐methyl‐transferase activity in the rat brain were measured after the administration of cocaine. Moreover, we examined the effect of l ‐histidine on cocaine‐induced wheel‐running behavior. The administration of cocaine (20 mg/kg) increased histamine levels and histamine N ‐methyltransferase activity in the striatum, nucleus accumbens, and amygdala 1 h later. The pretreatment with l ‐histidine (350 and 700 mg/kg) inhibited the cocaine (20 mg/kg)‐induced increase of wheel‐running activity in a dose‐dependent manner. These findings suggest that cocaine activates the brain histamine neuron system, which may play the role of inhibiting the cocaine‐induced wheel‐running behavior.