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Differential Oligodendroglial Expression of the Tumor Necrosis Factor Receptors In Vivo and In Vitro
Author(s) -
Tchélingérian JeanLéon,
Monge Madeleine,
Le Saux Françoise,
Zalc Bernard,
Jacque Claude
Publication year - 1995
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1995.65052377.x
Subject(s) - tumor necrosis factor alpha , oligodendrocyte , receptor , multiple sclerosis , cytokine , biology , in vivo , immune system , immunology , microbiology and biotechnology , myelin , neuroscience , central nervous system , biochemistry
The cytokine tumor necrosis factor‐α (TNFα) has been proposed to play a key role in the degenerative processes observed in demyelinating diseases such as multiple sclerosis (MS). In the immune system the cellular responses to TNF are mediated by two different receptors: TNF‐RI, which is involved in cell death, and TNF‐RII, which has been shown to mediate cell proliferation. We investigated the oligodendroglial expression of TNF‐RI and ‐RII. In vivo, in normal adult rodent brain, oligodendrocytes express TNF‐RII but not TNF‐RI. However, after 3 days in culture, both types of receptors were expressed by mature oligodendrocytes, purified from 4‐week‐old rats, suggesting that expression of TNF‐RI was induced by either the isolation process or the culture conditions. This inducibility of TNF‐RI may explain the differences in oligodendrocyte cell death reported in various experimental conditions and in the pathology of MS lesions.