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Schwannoma‐Derived Growth Factor Interacts with the Epidermal Growth Factor Receptor
Author(s) -
Maher Pamela A.,
Schubert David
Publication year - 1995
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1995.65041895.x
Subject(s) - epidermal growth factor , epidermal growth factor receptor , growth factor receptor inhibitor , receptor , cancer research , growth factor receptor , tgf alpha , tyrosine phosphorylation , biology , microbiology and biotechnology , phosphorylation , endocrinology , medicine , signal transduction , biochemistry
Schwannoma‐derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF receptor but not HER2/neu.