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Effect of Acute Fluoxetine Treatment on the Brain Serotonin Synthesis as Measured by the α‐Methyl‐ l ‐Tryptophan Autoradiographic Method
Author(s) -
Tsuiki Ko,
Yamamoto Y. Lucas,
Diksic Mirko
Publication year - 1995
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1995.65010250.x
Subject(s) - serotonin , fluoxetine , endocrinology , medicine , serotonin reuptake inhibitor , hippocampus , chemistry , tryptophan , substantia nigra , caudate nucleus , tryptophan hydroxylase , pharmacology , serotonergic , biochemistry , dopamine , receptor , dopaminergic , amino acid
The effect of treatment with acute fluoxetine, a serotonin reuptake inhibitor, on the rate of serotonin synthesis in the rat brain was studied through autoradiography following intravenous administration of α‐methyl‐ l ‐[ 3 H]tryptophan. The rate of serotonin synthesis in fluoxetine‐treated rats was compared with the rate measured in sham‐treated rats (saline injection). Results showed a significant increase in the rate of synthesis in the majority of cerebral structures examined. The greatest increase (given as a percentage of rates in control animals) in the rate of serotonin synthesis was observed in the substantia nigra compacta (344%), hippocampus‐CA3 (337%), dorsal hippocampus (283%), and caudate‐putamen (232%). Fluoxetine had a less significant effect on the rate of synthesis in the pineal body (44%). Data suggest that acute fluoxetine treatment (30 mg/kg, i.p.) enhances the rate of serotonin synthesis in all the structures of rat brain examined in this work.