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Neuronal Glucoprivation Enhances Hypothalamic Histamine Turnover in Rats
Author(s) -
Oohara Akihiko,
Yoshimatsu Hironobu,
Kurokawa Mamoru,
Oishi Ryozo,
Saeki Kiyomi,
Sakata Toshiie
Publication year - 1994
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1994.63020677.x
Subject(s) - histamine , hypothalamus , endocrinology , neuroscience , chemistry , medicine , biology
Histamine (HA) turnover in the rat hypothalamus following insufficient energy supply due to glucoprivation was examined after administration of insulin or 2‐deoxy‐ d ‐glucose (2‐DG). HA turnover was assessed by accumulation of tele ‐methylhistamine ( t ‐MH), a major metabolite of brain HA, following administration of pargyline. Intraperitoneal injection of 1, 2, and 4 U/kg of insulin, which had no influence on steady‐state levels of HA and t ‐MH, increased pargyline‐induced accumulation of t ‐MH. Accumulation of t ‐MH due to pargyline was inversely related to the concomitant plasma glucose concentration after different doses of insulin. The level of t ‐MH accumulated by pargyline did not change compared with that of controls, when a euglycemic condition was maintained or insulin at a dose of 6 mU per rat was infused into the third cerebroventricle. Intracerebroventricular infusion of 24 µmol per rat of 2‐DG, which had no influence on steady‐state levels of HA and t ‐MH, increased the level of t ‐MH enhanced by pargyline. The results indicate that an increase in hypothalamic HA turnover in response to glucoprivation may be involved in homeostatic regulation of energy metabolism in the brain.