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Preferential Stimulation of Extracellular Release of Dopamine in Rat Frontal Cortex to Striatum Following Competitive Inhibition of the N ‐Methyl‐ d ‐Aspartate Receptor
Author(s) -
Nishijima Koichi,
Kashiwa Atsushi,
Nishikawa Toru
Publication year - 1994
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1994.63010375.x
Subject(s) - homovanillic acid , dopamine , nmda receptor , chemistry , microdialysis , striatum , 3,4 dihydroxyphenylacetic acid , 2 amino 5 phosphonovalerate , dopamine receptor d1 , endocrinology , medicine , neuroscience , dopamine receptor , receptor , excitatory amino acid antagonists , biology , biochemistry , serotonin
Using a brain microdialysis technique, we have shown in the rat that local infusion of a selective and competitive N ‐methyl‐ d ‐aspartate (NMDA) receptor antagonist, cis ‐4‐phosphonomethyl‐2‐piperidine carboxylic acid (CGS‐19755), into the medial frontal cortex via dialysis tubing caused a concentration‐related increase in the extracellular release of dopamine, 3,4‐dihydroxyphenylacetic acid, and homovanillic acid in the cortical region. Coinfusion of a sodium channel blocker, tetrodotoxin, completely inhibited the ability of the NMDA antagonist to augment frontal dopamine metabolism. These findings suggest that dopamine neurons projecting to the frontal cortex might be under a tonic transsynaptic inhibition exerted by excitatory amino acid neurotransmission via the NMDA receptor at the level of dopamine terminal fields.