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Diurnal Variations in Cyclic AMP and Melatonin Content of Golden Hamster Retina
Author(s) -
Faillace María P.,
Sarmiento María I. Keller,
Siri Leonardo Nicola,
Rosenstein Ruth E.
Publication year - 1994
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1994.62051995.x
Subject(s) - melatonin , darkness , golden hamster , hamster , medicine , endocrinology , retina , biology , retinal , circadian rhythm , photoperiodism , mesocricetus , diurnal temperature variation , incubation , chemistry , botany , biochemistry , neuroscience , atmospheric sciences , geology
The diurnal variations and photic regulation of cyclic AMP and melatonin content in golden hamster retina were studied. Both parameters showed significant diurnal variations with maximal values at night. Light exposure during the night inhibited retinal cyclic AMP and melatonin levels, whereas exposure to darkness during the day significantly increased cyclic AMP and melatonin content. Incubation with melatonin of retinas excised at different intervals indicated that the methoxyindole inhibited cyclic AMP accumulation in a time‐dependent manner. The inhibitory effect of melatonin at 2400 h and at noon showed a threshold concentration of 1 and 10 pM , respectively. At 0400 h melatonin did not affect cyclic AMP accumulation. The results indicate a diurnal variability of retinal cyclic AMP and melatonin content in hamsters, mainly influenced by a photic stimulus. Cyclic AMP could be a putative second messenger for melatonin action in golden hamster retina.