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Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman
Author(s) -
Razzi Sandro,
Fava Antonio,
Sartini Annalisa,
Simone Simona,
Cobellis Luigi,
Petraglia Felice
Publication year - 2004
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1046/j.1471-0528.2003.00038.x
Subject(s) - obstetrics and gynaecology , medicine , reproductive medicine , gynecology , obstetrics , family medicine , pregnancy , biology , genetics
Endometriosis is a chronic and progressive diseasemanifested by chronic pelvic pain and infertility and whichmay affect 2–10% of women of reproductive age. Becauseit is an oestrogen-dependent disease, the goal of currentmedical therapy is to induce hypoestrogenism or to antagoniseoestrogen action.Oestrogen biosynthesis in women of reproductive agetakes place primarily in the ovary, while after spontaneousor surgical menopause, the adipose tissue and adrenal glandsare the main source.1 Aromatase P450 catalyses the conversionof androstenedione of adrenal origin to oestrogens,endometriotic tissues express it2–4 and prostaglandins arethe most potent known aromatase stimulator in endometrioticstromal cells