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Interleukin‐1 receptor antagonist polymorphism in women with peritoneal adhesions
Author(s) -
Wieser Fritz,
Tempfer Clemens,
Schneeberger Christian,
Trotsenburg Michael,
Huber Johannes,
Wenzl Rene
Publication year - 2002
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1046/j.1471-0528.2002.01087.x
Subject(s) - medicine , genotype , allele , univariate analysis , interleukin 1 receptor antagonist , adhesion , gastroenterology , surgery , receptor , receptor antagonist , antagonist , multivariate analysis , gene , genetics , biology , chemistry , organic chemistry
Interleukin (IL)‐1 has been shown to induce peritoneal adhesions. We determined the IL‐1 receptor antagonist (IL‐1RN) genotype with respect to the two most common variant alleles IL‐1RN*2 and IL‐1RN*3 in Caucasian women with peritoneal adhesions. One hundred seven women with surgically verified peritoneal adhesions and 79 controls without peritoneal adhesions served as controls. Univariate analysis showed an increased risk for peritoneal adhesions for Caucasian women carrying the mutant IL‐1RN*2 allele (OR: 2.1; 95% CI: 1.3–3.4; P = 0.004 ). Multiple logistic regression analysis demonstrated an increased risk for peritoneal adhesions, which is independent of previous abdominal surgery and endometriosis. Our data suggest that IL‐1RN*2 allele carriers have an increased risk for adhesion formation.