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Forkhead transcription factors are targets of signalling by the proto‐oncogene PKB (C‐AKT)
Author(s) -
KOPS G. J. P. L.,
BURGERING B. M. T.
Publication year - 2000
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.2000.19740571.x
Subject(s) - protein kinase b , transcription factor , kinase , microbiology and biotechnology , foxo3 , pi3k/akt/mtor pathway , phosphorylation , biology , cancer research , signal transduction , genetics , gene
Following the discovery that the proto‐oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3′‐kinase (PI3‐kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3‐kinase dependent cellular responses. Most recently PKB‐dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3‐kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3‐kinase dependent cellular responses.