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Expression of three oligosaccharide conjugates by neonatal rat dorsal root ganglion neurons: comparison with CGRP and GAP43 immunoreactivity
Author(s) -
GROVES M. J.,
MARTINIAN L.,
AN S.F.,
SCARAVILLI F.
Publication year - 1999
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.1999.19520271.x
Subject(s) - gap 43 protein , calcitonin gene related peptide , dorsal root ganglion , immunohistochemistry , oligosaccharide , microbiology and biotechnology , biology , ganglion , immunochemistry , embryonic stem cell , anatomy , immunology , neuropeptide , biochemistry , dorsum , receptor , gene , antibody
Adult dorsal root ganglion neurons express oligosaccharides conjugated to lipids that may be involved in cell–cell recognition, and consequently in the laminar organisation of their central terminations. This paper describes an immunohistochemical study of the developmental expression of 2 lactoseries (LA4 and LD2) and 1 globoseries (SSEA4) oligosaccharide conjugates in rats from embryonic d 19 to postnatal d 60. The expression of calcitonin gene related peptide and the growth associated protein GAP43 was also examined for comparative purposes. We found that these oligosaccharide conjugates begin to be expressed after birth, suggesting that they may be involved in maturation of the central or peripheral terminations, rather than axonal guidance.