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Axon guidance of outgrowing corticospinal fibres in the rat
Author(s) -
JOOSTEN ELBERT A. J.,
BÄR DOP P. R.
Publication year - 1999
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.1999.19410015.x
Subject(s) - corticospinal tract , neuroscience , spinal cord , axon , pyramidal tracts , central nervous system , axon guidance , biology , anatomy , sensory system , motor system , nervous system , medicine , radiology , diffusion mri , magnetic resonance imaging
This review is concerned with the development of the rat corticospinal tract (CST). The CST is a long descending central pathway, restricted to mammals, which is involved both in motor and sensory control. The rat CST is a very useful model in experimental research on the development of fibre systems in mammals because of its postnatal outgrowth throughout the spinal cord as well as its experimental accessibility. Hence mechanisms underlying axon outgrowth and subsequent target cell finding can be studied relatively easily. In this respect the corticospinal tract forms an important example and model system for the better understanding of central nervous system development in general.