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Pathways of interstitial fluid and lymph flow in the liver acinus of the sheep and mouse
Author(s) -
HEATH TREVOR,
LOWDEN STEWART
Publication year - 1998
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.1998.19230351.x
Subject(s) - interstitial space , perisinusoidal space , acinus , lymphatic system , anatomy , portal vein , interstitial fluid , pathology , limiting , lymph , biology , medicine , pancreas , hepatocyte , radiology , mechanical engineering , biochemistry , engineering , in vitro
In the acinus of the sheep and mouse liver, lymphatic vessels are restricted to the portal tracts. Vessels less than about 25 μm across form a network around portal venules, and are closely associated with the limiting plate of hepatocytes. The perisinusoidal space of Disse is continuous with the interstitial space of the portal tracts at the origin of the sinusoids. It seems likely that excess interstitial fluid derived from the sinusoids flows along the perisinusoidal space of Disse to enter the portal tracts near the portal venules, and then enters the small lymphatics which lie adjacent to those venules. It then enters the larger vessels, which are adjacent to hepatic arterioles and bile ductules.