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Review. Articular cartilage chondrons: form, function and failure
Author(s) -
POOLE C. ANTHONY
Publication year - 1997
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.1997.19110001.x
Subject(s) - articular cartilage , osteoarthritis , chondrocyte , cartilage , hyaline cartilage , hyaline , medicine , anatomy , bioinformatics , biology , pathology , alternative medicine
The chondrocyte and its pericellular microenvironment together represent the chondron, historically considered the primary structural, functional and metabolic unit of articular and other hyaline cartilages. This review summarises research over the last 10 years to establish the molecular anatomy, functional properties and metabolic contribution of the chondron in articular cartilage homeostasis, and its failure during the initiation and progression of degenerative osteoarthritis.