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Investigation of the influence of the Mm musculus MyoD1 allele on the efficiency of skeletal muscle regeneration
Author(s) -
MARLOW S. A.,
KAY P. H.,
McGEACHIE J. K.,
PAPADIMITRIOU J. M.
Publication year - 1997
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.1997.19020223.x
Subject(s) - skeletal muscle , biology , subspecies , allele , regeneration (biology) , phenotype , house mouse , genetics , gene , anatomy , zoology
MyoD1 alleles distinguish between the Mm musculus and Mm domesticus subspecies of Mus musculus . SJL/J mice, which belong to the Mm musculus subspecies, are able to regenerate skeletal muscle more efficiently than BALB/c mice which possess the Mm domesticus MyoD1 allele. Hence the possibility that regeneration responses are due to species‐specific genetic differences including MyoD1 was investigated in this study. Quantitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenotype is not species‐specific and may not be directly related to MyoD1 alleles. These results contrast with prior investigations conducted in SJL/J and BALB/c mice, and indicate that other genes may have a direct influence on skeletal muscle regeneration.