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Northwest African distribution of the CD4 / Alu microsatellite haplotypes
Author(s) -
FLORES C.,
MACAMEYER N.,
GONZÁLEZ A. M.,
CABRERA V. M.
Publication year - 2000
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.2000.6440321.x
Subject(s) - haplotype , microsatellite , distribution (mathematics) , alu element , biology , evolutionary biology , genetics , geography , genotype , allele , mathematics , gene , genome , human genome , mathematical analysis
We have analysed a linked microsatellite/ Alu polymorphism at the CD4 locus ( CD4 / Alu ) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub‐Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu (−) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub‐Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(−) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.