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Hardy–Weinberg quality control
Author(s) -
GOMES I.,
COLLINS A.,
LONJOU C.,
THOMAS N. S.,
WILKINSON J.,
WATSON M.,
MORTON N.
Publication year - 1999
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1999.6360535.x
Subject(s) - genotyping , linkage (software) , genetics , outlier , genome scan , statistics , biology , hardy–weinberg principle , genome , type i and type ii errors , typing , mathematics , allele frequency , genotype , allele , gene , microsatellite
An efficient test of deviation from Hardy–Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (χ 2 (1) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.