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A CORRECTION TO TDT STATISTICS FOR MAPPING QUANTITATIVE TRAIT LOCI
Author(s) -
Wang J.,
Cohen J.
Publication year - 1999
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1999.6350469.x
Subject(s) - statistic , locus (genetics) , linkage disequilibrium , genetics , transmission disequilibrium test , quantitative trait locus , biology , allele , trait , confusion , test statistic , statistics , haplotype , statistical hypothesis testing , mathematics , gene , psychology , computer science , psychoanalysis , programming language
Xiong et al. (1998) proposed a general transmission disequilibrium test (TDT) for quantitative traits. Their TDT for quantitative traits permits more than one child and more than one heterozygous parent per family. This TDT is also appropriate for the situation where the trait and marker loci are at varying degrees of linkage and linkage disequilibrium. Their generalized TDT statistic for a multi‐allele marker locus may be more useful in practice. However, there are several mistakes in their mathematical presentation for this generalized TDT statistic for a multi‐allele marker locus, and it confuses readers. Here, we present a corrected TDT statistic for a multi‐allele marker locus with a clearer presentation. We hope that this new presentation will remove some confusion for readers.