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Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies
Author(s) -
ARINAMI T.,
IIJIMA Y.,
YAMAKAWAKOBAYASHI K.,
ISHIGURO H.,
OHTSUKI T.,
YANAGI H.,
SHIMAKURA Y.,
ISHIKAWA H.,
HAMAGUCHI H.
Publication year - 1999
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1999.6320147.x
Subject(s) - heritability , short stature , genetics , biology , genotyping , genetic association , genetic linkage , candidate gene , gene , polymorphism (computer science) , genotype , single nucleotide polymorphism , endocrinology
Increases in height were reported in children chronically exposed prenatally and postnatally to D2 receptor‐blocking drugs. A possible haplotypic association between stature and the DRD2 gene was also reported. In this study, we examined linkage between stature and DRD2 by genotyping a dinucleotide repeat polymorphism in 79 sib‐pairs aged 8–17 years. An association between stature and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in the sib‐pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage ( p = 0.004, SIBPAL) and an association ( p = 0.009, paired t ‐test, in the sib‐pairs; p = 0.006, ANOVA, in the adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that contribute to heritability of stature.