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Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16
Author(s) -
CAVANAUGH J. A.,
CALLEN D. F.,
WILSON S. R.,
STANFORD P. M.,
SRAML M. E.,
GORSKA M.,
CRAWFORD J.,
WHITMORE S. A.,
SHLEGEL C.,
FOOTE S.,
KOHONENCORISH M.,
PAVLI P.
Publication year - 1998
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1998.6240291.x
Subject(s) - inflammatory bowel disease , ulcerative colitis , disease , pedigree chart , crohn's disease , chromosome , genetics , biology , medicine , gene , gastroenterology
A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al . (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis (Ohmen et al . 1996; Parkes et al . 1996). We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.