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Increased parental age and number of pregnancies in Klippel–Trenaunay–Weber syndrome
Author(s) -
LORDASANCHEZ I.,
PRIETO L.,
RODRIGUEZPINILLA E.,
MARTINEZFRÍAS M. L.
Publication year - 1998
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1998.6230235.x
Subject(s) - klippel trenaunay syndrome , epidemiology , inheritance (genetic algorithm) , genetics , pediatrics , medicine , biology , pathology , soft tissue , gene
The Klippel–Trenaunay–Weber syndrome (KTWS) is generally thought to occur sporadically, following a somatic mutation model. However, in some cases, clinical manifestations of the syndrome have been found in family members, suggesting an autosomal dominant inheritance. Here we present an epidemiological analysis of a consecutive series of cases with KTWS identified in the Spanish Collaborative Study of Congenital Malformations (ECEMC). We found an increase in parental age and in the number of pregnancies, as well as familial occurrence of haemangiomas. These observations suggest a genetic contribution to the occurrence of KTWS.