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Mapping of human interferon regulatory factor 3 ( IRF3 ) to chromosome 19q13.3–13.4 by an intragenic polymorphic marker
Author(s) -
BELLINGHAM J.,
GREGORYEVANS K.,
GREGORYEVANS C. Y.
Publication year - 1998
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1998.6230231.x
Subject(s) - biology , genetics , genetic marker , gene , intron , gene mapping , synteny , microbiology and biotechnology , genetic linkage , chromosome
We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor ( IRF3 ) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3–13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1 . An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3–13.4 maps Irf3 to either mouse chromosome 7 or 17.