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HLA evidence for the lack of genetic heterogeneity in Basques
Author(s) -
COMAS D.,
CALAFELL F.,
MATEU E.,
PÉREZLEZAUN A.,
BERTRANPETIT J.
Publication year - 1998
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1998.6220123.x
Subject(s) - analysis of molecular variance , biology , human leukocyte antigen , population , genetics , genetic diversity , principal component analysis , genetic heterogeneity , evolutionary biology , genetic variation , demography , genetic structure , statistics , gene , sociology , mathematics , phenotype , antigen
To examine the possible internal heterogeneity within the Basque population, nine samples typed for several HLA loci were compiled and HLA‐A, B, C and DR loci were analysed. First, the shared features of HLA in Basques were analysed by principal component analysis and genetic distances. Two major Basque dialect groups (‘French’ and ‘Spanish’) were considered. F ST statistics were computed and corrected for sampling intensity. The dialectal and political division did not seem to differentiate these two groups genetically. Analysis of Molecular Variance also failed to show consistently significant genetic variance components between French and Spanish Basques. Thus, in this particular example, linguistic diversity does not seem to correlate with a genetic stratification.