Premium
Molecular characterization of isochromosomes of Xq
Author(s) -
JAMES R. S.,
DALTON P.,
GUSTASHAW K.,
WOLFF D. J.,
WILLARD H. F.,
MITCHELL C.,
JACOBS P. A.
Publication year - 1997
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1997.6160485.x
Subject(s) - isochromosome , genetics , biology , centromere , x chromosome , x inactivation , chromosome , y chromosome , evolutionary biology , gene , karyotype
We have undertaken a study of 35 patients with i(Xq) to determine whether those that are maternally derived originate by similar mechanisms to those that are paternally derived. Isochromosome formation is not associated with increased parental age and >90% of i(Xq) contain proximal Xp sequences suggesting that centromere misdivision is not a common mechanism of formation. Our results indicate that the majority of i(Xq) originate from a single X chromosome and the usual mechanisms of formation do not appear to differ according to the parent of origin.