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Testing a genetic equilibrium across strata
Author(s) -
NAM J.M.
Publication year - 1997
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1997.6120163.x
Subject(s) - hardy–weinberg principle , wald test , statistics , mathematics , disequilibrium , statistic , goodness of fit , score test , test statistic , linkage disequilibrium , sample size determination , odds , exact test , chi square test , type i and type ii errors , test (biology) , econometrics , likelihood ratio test , statistical hypothesis testing , logistic regression , allele frequency , allele , biology , genetics , medicine , ophthalmology , haplotype , gene , paleontology
A score statistic for testing the Hardy–Weinberg law for data sampled from several populations with different allele frequencies is derived assuming a common coefficient of disequilibrium (odds ratio‐type) across strata. The assumption can be examined by a chi‐square goodness‐of‐fit test. It is unlikely such a model would be rejected in typical studies involving human populations. Under this model, a Wald‐type test has substantially less power than the score test. An approximate formula for the sample size required for a specific power of the stratified score test for detecting departure from equilibrium is given.