Premium
Influence of pepsinogen gene polymorphisms on serum pepsinogen
Author(s) -
YAMAGATA Z.,
ZHANG Y.,
SHINOZAKI S.,
MIYAMURA T.,
IIJIMA S.,
ASAKA A.,
KOBAYASHI K.
Publication year - 1997
Publication title -
annals of human genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 77
eISSN - 1469-1809
pISSN - 0003-4800
DOI - 10.1046/j.1469-1809.1997.6120093.x
Subject(s) - allele , genetics , biology , genotype , heterozygote advantage , microbiology and biotechnology , gene , pepsin , exon , population , polymorphism (computer science) , allele frequency , medicine , biochemistry , enzyme , environmental health
We identified pepsinogen C (PGC) gene polymorphisms by means of PCR, which amplified DNA in the region within the intron between exons 7 and 8, and by 6% polyacrylamide gel electrophoresis. Six alleles were found in a Japanese population. The frequencies of these alleles in 408 unrelated Japanese individuals were 0·074, 0·026, 0·335, 0·237, 0·016 and 0·314, respectively. The serum pepsinogen II level significantly decreased in the order of the allele 6 homozygote, the allele 6 heterozygote and the other genotypes (χ 2 =7·850, d.f. =2, p =0·020). These findings indicated that the genetic background of serum pepsinogen should be considered when screening for stomach cancer by this procedure.