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Prognostic significance of ultrasound derived intratumoral peak systolic velocity in epithelial ovarian cancer
Author(s) -
Hata K.,
Yoshida M.,
Maruyama R.,
Fujiwaki R.,
Miyazaki K.
Publication year - 2002
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2002.00748.x
Subject(s) - thymidine phosphorylase , medicine , stage (stratigraphy) , pathology , univariate analysis , microvessel , immunohistochemistry , terminal deoxynucleotidyl transferase , cancer , tunel assay , multivariate analysis , biology , paleontology
Objective To evaluate the prognostic significance of ultrasound derived intratumoral peak systolic velocity in epithelial ovarian cancer. Design Color Doppler imaging and pulsed Doppler spectral analysis were used in the investigation of 49 patients with epithelial ovarian cancer (19 serous, 15 mucinous, eight endometrioid, four clear cell and three Brenner cell) immediately before laparotomy. Twenty‐two were stage I, six were stage II, 17 were stage III and four were stage IV. Sections of malignant tumors were analyzed for the cellular expression of thymidine phosphorylase and the intratumoral density of microvessels by immunohistochemistry using antibodies to thymidine phosphorylase and factor VIII‐related antigen, respectively. Moreover, the apoptotic index was evaluated by the terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick end‐labeling method. Intratumoral peak systolic velocity was tested for correlation with patients' age at diagnosis, stage of disease, presence of a residual tumor, histological subtype and grade, thymidine phosphorylase expression, apoptotic index, microvessel count and patient survival. Results Histological grade ( P = 0.025), thymidine phosphorylase expression ( P = 0.044), apoptotic index ( P = 0.039) and microvessel count ( P = 0.014) were all significantly associated with peak systolic velocity. Stage of disease ( P = 0.002), presence of residual disease ( P = 0.0002) and peak systolic velocity ( P = 0.041) were found by univariate Cox regression analysis to be significantly associated with a poor prognosis. Multivariate Cox regression analysis revealed that stage of disease ( P = 0.006) and peak systolic velocity ( P = 0.008) are independent prognostic factors. Conclusions Intratumoral peak systolic velocity could be a preoperatively pertinent prognostic predictor of survival in patients with epithelial ovarian cancer. Copyright © 2000 International Society of Ultrasound in Obstetrics and Gynecology